Authors - Marwan Babiker, Eda Merisalu, Zenija Roja, Henrijs Kalkis Abstract - A Health Information System (HIS) is an electronic database of managerial and clinical information, which allows physicians to utilize quality improvement processes in clinical practice and support multiple services in healthcare organizations. According to research, physician satisfaction varies greatly and is frequently correlated with particular features and the ease of exchanging information. The study aimed to identify the traits of doctors' acceptability of using a hospital information system (HIS) and their degree of satisfaction with it. It is a cross-sectional study that used an online self-administered survey, which was conducted among all 56 physicians working in family medicine centers in the Royal Commission health service program, Saudi Arabia. The questionnaire was used to assess the physician’s satisfaction level about the two structures that will be examined: system quality and satisfaction level. The findings showed that the physicians in the family medicine centers have a high agreement proportion about the use and satisfaction of the use of HIS, which indicates a high quality of the HIS. The outcomes measure system excellence and user satisfaction when assessing the effectiveness of HIS in several domains. The participating physicians expressed satisfaction with the way HIS improved their clinical processes and how reliable it was for patient care. More longitudinal studies are required to understand the indicator of physician satisfaction with the HIS use.