Authors - Sunday Adeola AJAGBE, Oluwatobi AKINLADE, Korede Israel ADEYANJU, Olajide KUTI, Ademola Olusola ADESINA, Matthew O. ADIGUN Abstract - Many suggested projects carried out using a cryptography key are meant to guarantee security and privacy of Health Information Systems (HIS). Still, HIS's weakest flaw depending on these cryptographic techniques is key management and resource consumption in computers. This work presents an experimental comparison of asymmetric and symmetric cryptography keys; specifically, RSA (asymmetric) and AES, (symmetric), to ascertain effectiveness and efficiency with respect to the level of consumption of computer resources viz-a-viz Processing Time, computing memory, and CPU consumption. Using the anonymised dataset at https://wiki.openmrs.org/display/RES/Demo+Data, which has been ad-judged to fit for study, was undertaken. The results reveal that through-out the experiment, HIS data increases the RSA and AES both in processing time although RSA indicates higher value compare to AES in all the HIS input. In the same vein, memory usage for the RSA and AES rises as HIS data rises across the trial. For processor consumption, while RSA consistently increased, AES increased only twice, the first one was when HIS input increased from 500 to 1000, AES increased from 0 to 0.01 respectively. Also, HIS input increased from 4500 to 5000, AES increased from 0.01 to 0.03 respectively.