Authors - Muhammad Al-Zafar Khan, Jamal Al-Karaki, Marwan Omar Abstract - In this paper, we present a multi-agent reinforcement learning (MARL) framework for optimizing tissue repair processes using engineered biological agents. Our approach integrates: (1) Stochastic reaction-diffusion systems modeling molecular signaling, (2) Neural-like electrochemical communication with Hebbian plasticity, and (3) A biologically informed reward function combining chemical gradient tracking, neural synchronization, and robust penalties. A curriculum learning scheme guides the agent through progressively complex repair scenarios. In silico experiments demonstrate emergent repair strategies, including dynamic secretion control and spatial coordination.
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