Authors - Wolf A. Kafka, Gunther Bernatzky, Pravir Malik Abstract - Chronic fatigue, sleep disturbances, and mental exhaustion are increasingly prevalent in modern societies, necessitating innovative, non-invasive therapeutic solutions. This study evaluates the impact of the Centropix KLOUD Pulsed Electromagnetic Activation (PEMA) system on various dimensions of human well-being. Conducted by an independent research group (SFU Vienna), the study involved 428 participants (aged 19–84) across Germany, Austria, Switzerland, and the USA. Participants used the KLOUD device—a full-body electromagnetic field mat delivering broadband pulsed stimulation—for 15 minutes daily over 42 days. Validated assessment tools, including the Veterans RAND- 12, Fatigue Assessment Scale (FAS), Jenkins Sleep Scale, and NRS-11 for discomfort, were used to measure outcomes at baseline (T-0) and after the intervention (T-1). Results revealed statistically significant reductions in exhaustion, and improvements in mental performance, energy levels, and sleep quality. In a key subgroup (n = 103) identified with severe exhaustion symptoms at baseline, only 14.9 % continued to report such symptoms after the intervention—an 85.1 % reduction. These findings suggest that the KLOUD-PEMA system offers clinically relevant benefits for enhancing vitality and resilience without side effects, supporting its role in primary and secondary preventive health strategies. The technology’s simplicity, accessibility, and safety profile make it a compelling candidate for broader integrative health applications.